Idiopathic Tropical Splenomegaly Syndrome in IbadanBr Med J 1968; 4 doi: https://doi.org/10.1136/bmj.4.5634.793 (Published 28 December 1968) Cite this as: Br Med J 1968;4:793
- E. J. Watson-Williams,
- N. C. Allan
Follow-up of 33 patients with idiopathic splenomegaly, 25 for a period ranging from 14 to 80 months after starting treatment with proguanil 100 mg. daily, showed that there was an excellent response of the splenomegaly, anaemia, and hepatomegaly, together with a definite gain in weight. Every patient improved, though a maximum result was not attained until after at least one year's treatment.
Therapy with proguanil is considered superior to and safer than splenectomy. Malaria seems unlikely to have a causal role in the aetiology of the disease, which is probably a manifestation of a disorder of the normal immune mechanism. Idiopathic splenomegaly has a close relation with the type of chronic lymphatic leukaemia seen in Nigeria, and it is possible that the two diseases have a similar aetiological factor.
↵* From the Department of Pathology, University of Ibadan, Nigeria.