Comparison of the Adrenocorticotrophic Activities of Two Synthetic Polypeptides: Synacthen and DW 75Br Med J 1968; 4 doi: https://doi.org/10.1136/bmj.4.5629.487 (Published 23 November 1968) Cite this as: Br Med J 1968;4:487
- W. W. Downie,
- K. Whaley,
- Mary A. Wright,
- Margaret A. Bell,
- Anne K. Taylor
The adrenocorticotrophic activities of two synthetic polypeptides, Synacthen (Ciba) and DW 75 (Sandoz), were compared in two groups of patients having a variety of arthritic disorders. Compared with Synacthen, injected either intramuscularly or intravenously, intravenous DW 75 was found to have a longer duration of adrenocorticotrophic activity (measured by plasma 11-hydroxycorticosteroid levels) in both groups of patients, while intramuscularly administered DW 75 did not appear to be absorbed well.
↵* From the Centre for Rheumatic Diseases, Baird Street, and the University Department of Medicine, Royal Infirmary, Glasgow C.4.