Papers And Originals

Prevention of Rhesus Immunization. A Controlled Clinical Trial with a Comparatively Low Dose of Anti-D Immunoglobulin

Br Med J 1968; 4 doi: https://doi.org/10.1136/bmj.4.5629.477 (Published 23 November 1968) Cite this as: Br Med J 1968;4:477

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  1. C. Dudok De Wit,
  2. E. Borst-Eilers,
  3. Ch.M. v. d. Weerdt,
  4. G. J. Kloosterman

    Abstract

    A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 μg) in preventing rhesus immunization.

    In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.