Prevention of Rhesus Immunization. A Controlled Clinical Trial with a Comparatively Low Dose of Anti-D ImmunoglobulinBr Med J 1968; 4 doi: https://doi.org/10.1136/bmj.4.5629.477 (Published 23 November 1968) Cite this as: Br Med J 1968;4:477
- C. Dudok De Wit,
- E. Borst-Eilers,
- Ch.M. v. d. Weerdt,
- G. J. Kloosterman
A controlled clinical trial was carried out to test the effectiveness of a comparatively low dose of anti-D immunoglobulin (250 μg) in preventing rhesus immunization.
In the control group 17 out of 329 women (5%) formed rhesus antibodies, whereas in the treated group only 3 out of 333 women (0.9%) showed active immunization, all three of whom had an exceptionally large transplacental bleeding.