Preliminary Communications

Counteraction of Platelet Activity at Sites of Laser-induced Endothelial Trauma

Br Med J 1968; 4 doi: (Published 16 November 1968) Cite this as: Br Med J 1968;4:430
  1. K-E. Arfors,
  2. H. C. Hint,
  3. D. P. Dhall,
  4. N. A. Matheson


    The effects of dextran 70 (Mw 70,000; Macrodex), heparin, dipyridamole (Persantin), and prostaglandin E1 on the behaviour of platelets were investigated at sites of endothelial trauma induced with a ruby biolaser in arterioles in the rabbit ear chamber. This technique has several advantages over previous methods of studying platelet activity.

    Dextran 70 (2 g./kg. body weight) caused a profound reduction in platelet activity four to six hours after its administration. Heparin (12 mg./kg. body weight) had no effect. The effect of dipyridamole (2.5 mg./kg. body weight) was profound immediately after its administration, but was transient. In preliminary experiments single intravenous injections of prostaglandin E1 (25 and 125 μg./kg. body weight) had no detectable effect.

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