Papers And Originals

Medullary Carcinoma and Thyrocalcitonin

Br Med J 1968; 4 doi: http://dx.doi.org/10.1136/bmj.4.5623.87 (Published 12 October 1968) Cite this as: Br Med J 1968;4:87
  1. M. Tubiana,
  2. G. Milhaud,
  3. G. Coutris,
  4. J. Lacour,
  5. C. Parmentier,
  6. B. Bok

    Abstract

    Seven patients with medullary carcinoma of the thyroid were investigated, and the thyrocalcitonin activity of the primary tumours, metastatic deposits, and the serum was estimated.

    Medullary carcinomas of the thyroid with amyloid stroma contain 100 to 600 times more thyrocalcitonin than normal thyroid tissue, and lymph nodes with metastatic deposits are equally rich in the hormone. High values of thyrocalcitonin are also found in the blood of these patients. Medullary carcinoma of the thyroid with amyloid stroma is the first disease to be recognized in which there is hypersecretion of thyrocalcitonin.

    Footnotes

    • * From the Département des Radiations, Institut Gustave-Roussy, 94-Villejuif, and Service de Biophysique, C.H.U. St. Antoine, 27 rue de Chaligny, Paris 12è.