Clinical trials registered prospectively are less likely to veer from protocols, study finds

Clinical trials that are registered prospectively on trial registries are more likely to be published without changes to the primary outcome or the study protocol than those not registered, a Finnish study has reported.1

“Journal editors, regulators, research ethics committees, funders, and sponsors should implement policies mandating prospective registration for all clinical trials,” said the study authors, led by An-Wen Chan, from the University of Toronto, Canada. …