Practice Clinical updates

Lassa fever

BMJ 2017; 358 doi: https://doi.org/10.1136/bmj.j2986 (Published 12 July 2017) Cite this as: BMJ 2017;358:j2986
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Click here for a visual overview of management for people with Lassa fever

  1. Catherine Houlihan, clinical lecturer in infectious diseases/virology1,
  2. Ron Behrens, consultant in tropical and travel medicine and senior lecturer2
  1. 1University College London, London, UK
  2. 2Hospital for Tropical Diseases, and London School of Hygiene and Tropical Medicine, London, UK
  1. Correspondence to: C Houlihan catherine.houlihan{at}lshtm.ac.uk

What you need to know

  • Lassa fever is a viral haemorrhagic fever endemic in West Africa

  • It is predominantly asymptomatic or results in mild febrile symptoms (about 80% of cases). Severe symptoms (such as haemorrhage, respiratory distress, repeated vomiting, facial swelling, shock) occur in around 20% of cases. Overall mortality is around 1%, but observed case fatality rate among hospitalised patients is reported to be up to 70%

  • Symptoms of Lassa fever can be difficult to distinguish from malaria and typhoid; therefore, other potentially serious illnesses should be considered in an individual returning from an endemic area with an appropriate history

  • Diagnosis is entirely dependent on an accurate history and an understanding of the geography of the disease, supported by laboratory investigations

  • Management involves early recognition of infection, effective isolation and infection control, early initiation of the antiviral drug ribavirin, and supportive care in hospital

  • Ribavirin is occasionally used as post-exposure prophylaxis for high risk exposure to Lassa virus

Lassa fever is part of a group of conditions known as viral haemorrhagic fevers. Viral haemorrhagic fevers can be caused by viruses from several different families, all of which have the potential to cause disease with haemorrhagic features.1

Lassa fever—caused by infection with the Lassa virus—is named after the town in Nigeria where the first identified cases occurred. The natural reservoir of the Lassa virus is the multimammate rat (Mastomys natalensis), a rodent found commonly in rural areas of tropical Africa that often colonises in or around human homes where food is stored.

Who gets it?

Lassa fever is endemic in parts of West Africa, including Sierra Leone, Liberia, Guinea, and Nigeria (fig 1). There also is evidence of endemicity in neighbouring countries.234

Fig 1 Distribution map of Lassa fever outbreaks (adapted from Centers for Disease Control and Prevention. Lassa fever. www.cdc.gov/vhf/lassa/index.html)

The …

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