Letters Genetic test for colorectal cancer

Urgent improvements needed to diagnose and manage Lynch syndrome

BMJ 2017; 356 doi: https://doi.org/10.1136/bmj.j1388 (Published 20 March 2017) Cite this as: BMJ 2017;356:j1388
  1. Kevin J Monahan, consultant gastroenterologist and honorary senior clinical lecturer1,
  2. Deborah Alsina, chief executive2,
  3. Simon Bach, consultant colorectal surgeon3,
  4. James Buchanan, health economist4,
  5. John Burn, professor of clinical genetics5,
  6. Sue Clark, professor and consultant colorectal surgeon6,
  7. Peter Dawson, president7,
  8. Bianca De Souza, clinical genetics registrar8,
  9. Farhat V N Din, senior lecturer and colorectal surgeon9,
  10. Sunil Dolwani, clinical senior lecturer and vice president10,
  11. Malcolm G Dunlop, head of colon cancer genetics11,
  12. James East, consultant gastroenterologist and honorary senior clinical lecturer12,
  13. D Gareth Evans, professor of medical genetics and cancer epidemiology13,
  14. Nicola Fearnhead, consultant colorectal surgeon and chair of research and committee14,
  15. Ian M Frayling, consultant in genetic pathology15,
  16. Rob Glynne-Jones, consultant clinical oncologist16,
  17. James Hill, professor of colorectal surgery17,
  18. Richard Houlston, professor18,
  19. Mark Hull, professor and consultant gastroenterologist19,
  20. Fiona Lalloo, consultant clinical geneticist20,
  21. Andrew Latchford, consultant gastroenterologist and honorary senior clinical lecturer21,
  22. Suzy Lishman, president22,
  23. Phil Quirke, professor and head of pathology and tumour biology23,
  24. Colin Rees, professor and vice president (chair of endoscopy)24,
  25. Matt Rutter, professor and consultant gastroenterologist25,
  26. Peter Sasieni, professor of biostatistics and cancer epidemiology26,
  27. Asha Senapati, consultant colorectal surgeon and chairman27,
  28. Doug Speake, colorectal surgeon28,
  29. Huw Thomas, professor of gastrointestinal genetics29,
  30. Ian Tomlinson, professor of genetics30
  1. 1Family History of Bowel Cancer Clinic, West Middlesex University Hospital, Chelsea and Westminster Hospitals NHS Trust; Imperial College London, London, UK
  2. 2Bowel Cancer UK
  3. 3Queen Elizabeth Hospital, Birmingham
  4. 4University of Oxford
  5. 5Newcastle University
  6. 6St Mark’s Hospital
  7. 7Association of Coloproctology for Great Britain and Ireland
  8. 8North West Thames Regional Genetics Service
  9. 9Western General Hospital, Edinburgh
  10. 10Cardiff University and Welsh Association of Gastroenterology and Endoscopy
  11. 11Colon Cancer Genetics Group and Academic Coloproctology, Institute of Genetics and Molecular Medicine
  12. 12Oxford University Hospitals
  13. 13University of Manchester
  14. 14Cambridge University Hospitals NHS Foundation Trust and Association of Coloproctology of Great Britain and Ireland
  15. 15University Hospital of Wales
  16. 16Mount Vernon Cancer Centre
  17. 17Central Manchester University Hospitals
  18. 18Institute of Cancer Research, London
  19. 19University of Leeds and Leeds Teaching Hospitals NHS Trust
  20. 20Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust
  21. 21St Mark’s Hospital and Imperial College London
  22. 22Royal College of Pathologists
  23. 23University of Leeds
  24. 24British Society of Gastroenterology
  25. 25University Hospital of North Tees
  26. 26Queen Mary University of London
  27. 27Bowel Disease Research Foundation
  28. 28Western General Hospital, Edinburgh
  29. 29St Mark's Hospital, Imperial College London
  30. 30University of Oxford
  1. k.monahan{at}imperial.ac.uk

Lynch syndrome is currently under-recognised, underdiagnosed, and undermanaged, so opportunities to reduce cancer mortality are often missed. The new guideline from the National Institute for Health and Care Excellence recommends universal testing for Lynch syndrome in all people newly diagnosed as having colorectal cancer.1 This should prevent several hundred colorectal cancers annually, but several issues hinder good care …

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