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Risks of duloxetine for stress incontinence outweigh benefits, say researchers

BMJ 2016; 355 doi: https://doi.org/10.1136/bmj.i6103 (Published 15 November 2016) Cite this as: BMJ 2016;355:i6103
  1. Barbara Kermode-Scott
  1. Vancouver Island

The antidepressant duloxetine should not be used to treat stress urinary incontinence in women because the harms outweigh the benefits, authors of a new analysis have said.

Although duloxetine reduced the symptoms of stress urinary incontinence and improved women’s quality of life, the harms related to suicidality and violence were 4 to 5 times more common with duloxetine than with a placebo, a meta analysis using patient level data by researchers from the Nordic Cochrane Centre showed.1

The researchers from Rigshospitalet in Copenhagen made their comments after conducting a meta-analysis using clinical study reports submitted to the European Medicines Agency for regulatory approval of duloxetine for stress urinary incontinence in women. They first gained access to clinical study …

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