Five minutes with . . . John Ioannidis

“We have an epidemic of deeply flawed meta-analyses, with the number published each year having increased by more than 2600% over the past 20 years, compared with only 50% for research studies of all types listed on PubMed.1

“There is now massive production of unnecessary, misleading, and conflicted systematic reviews and meta-analyses. While these designs represent the highest level of evidence, they are often massively misused, and …