Letters Epilepsy in pregnancy

Vitamin K is important for epilepsy in pregnancy

BMJ 2016; 354 doi: https://doi.org/10.1136/bmj.i3929 (Published 22 July 2016) Cite this as: BMJ 2016;354:i3929
  1. Mike Divers, consultant obstetrician and gynaecologist
  1. Noble’s Hospital, Isle of Man IM4 4RJ
  1. mike.divers{at}gov.im

I enjoyed Kinney and Morrow’s overview on epilepsy in pregnancy,1 but they did not comment on vitamin K supplementation in women taking enzyme inducing antiepileptic drugs (eg, carbamazepine, phenytoin, primidone, and phenobarbital). Vitamin K dependent clotting factors may be reduced in these babies, resulting in an increased risk of haemorrhagic disease in the newborn. Consequently, these women should be advised to take 10 mg prophylactic vitamin K orally from 36 weeks’ gestation, and the babies should be given 1 mg vitamin K parenterally at delivery.2


  • Competing interests: None declared.


View Abstract

Log in

Log in through your institution


* For online subscription