Letters Clinical risk factors for pre-eclampsia determined in early pregnancy

Authors’ reply to Thilagnathan

BMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i2889 (Published 24 May 2016) Cite this as: BMJ 2016;353:i2889
  1. Joel G Ray, clinician-scientist1,
  2. Emily Bartsch, medical student2
  1. 1Departments of Medicine, Health Policy Management and Evaluation, and Obstetrics and Gynecology, St Michael’s Hospital, University of Toronto, Toronto, Canada
  2. 2University of Toronto, Toronto, Canada
  1. rayj{at}smh.ca

In response to Thilagnathan’s comments,1 our paper identified several single risk factors that confer enough risk to justify aspirin prophylaxis in pregnancy (http://bit.ly/27Gw8LQ).2 For other risk factors, we recommend that two or more need to be present, again, based on our recent study. Maternal age over 40 years requires the presence of a second risk factor because its number needed to prevent was greater than 250.

We agree that our systematic review could …

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