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Therapeutic substitution could reduce US drug spending by nearly 10%, study finds

BMJ 2016; 353 doi: https://doi.org/10.1136/bmj.i2710 (Published 12 May 2016) Cite this as: BMJ 2016;353:i2710
  1. Michael McCarthy
  1. Seattle

The routine use of therapeutic substitution—where cheaper, chemically different compounds from the same therapeutic drug class are substituted for higher priced brand name drugs—could reduce US drug spending by nearly 10%, a new study in JAMA Internal Medicine has found.1

Unlike generic substitution—where a generic equivalent of a brand name drug is used—therapeutic substitution replaces the brand name drug with a drug with a different active ingredient but the same therapeutic effect, such as reducing blood pressure …

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