Research News

Meta-analysis finds no evidence for efficacy of nalmefene in treating alcohol dependence

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h6988 (Published 29 December 2015) Cite this as: BMJ 2015;351:h6988
  1. Susan Mayor
  1. 1London

Current evidence from randomised controlled trials does not support the use of the opioid antagonist nalmefene for treating alcohol dependence, shows a systematic review that the authors said questioned decisions by some regulatory authorities to approve the drug for this indication.

The review, published in PLoS Medicine, analysed all available randomised controlled trials evaluating nalmefene to treat alcohol dependence in adults.1 The researchers included five trials that met their inclusion criteria to compare the opioid antagonist with placebo, in 2567 adults with alcohol dependence.

Their results …

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