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Metformin in obese teenagers does not improve glycaemic control, study finds

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h6430 (Published 02 December 2015) Cite this as: BMJ 2015;351:h6430
  1. Jacqui Wise
  1. 1London

Adding metformin to insulin does not improve glycaemic control in overweight and obese adolescents with type 1 diabetes, a double blind placebo controlled randomised trial published in JAMA has found.1

For teenagers with type 1 diabetes, being overweight or obese potentially has serious metabolic consequences. High doses of insulin are needed to overcome the insulin resistance of obesity and puberty, contributing to difficulties in glycaemic control that may …

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