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Progesterone supplements do not reduce risk of recurrent miscarriage, study shows

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h6359 (Published 26 November 2015) Cite this as: BMJ 2015;351:h6359
  1. Susan Mayor
  1. 1London

Progesterone supplements in the first trimester of pregnancy do not improve the rate of live births in women who have unexplained recurrent miscarriages, shows a large study published in the New England Journal of Medicine.1

The study selected 826 women who were trying to conceive naturally after three or more recurrent losses of pregnancy in the first trimester and randomised them to twice daily treatment with vaginal suppositories containing 400 mg of micronised progesterone or matched placebo. They …

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