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Early use of azithromycin may reduce severity of wheezing, study finds

BMJ 2015; 351 doi: http://dx.doi.org/10.1136/bmj.h6153 (Published 18 November 2015) Cite this as: BMJ 2015;351:h6153
  1. Jacqui Wise
  1. 1London

Giving azithromycin to children with a history of recurrent severe lower respiratory tract illness may reduce the severity of further episodes, a randomised double blind placebo controlled trial published in JAMA has found,1 although experts warn that widespread use of such a strategy could result in increased antibiotic resistance.

The researchers randomised 607 children aged 12-71 months with a history of recurrent severe lower respiratory tract infection to receive azithromycin (12 mg/kg/day) for five days or placebo at the onset of symptoms that had previously …

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