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Buffered crystalloid solution shows no benefit over saline in critical care

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h5370 (Published 09 October 2015) Cite this as: BMJ 2015;351:h5370
  1. Jacqui Wise
  1. 1London

Using a buffered crystalloid solution instead of saline in the intensive care unit (ICU) did not reduce the risk of acute kidney injury in critically ill patients, a double blind randomised trial published in JAMA has found.1

Isotonic 0.9% sodium chloride (saline) is the most commonly used intravenous fluid in much of the world. However, concerns have arisen that the high chloride content of saline could contribute to the development of acute kidney injury. An alternative to saline is …

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