Dengue feverBMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h4661 (Published 15 September 2015) Cite this as: BMJ 2015;351:h4661
- Senanayake A M Kularatne, senior professor of medicine
- 1Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
The bottom line
Dengue fever is a globally important arboviral infection transmitted by the Aedes genus of mosquito (primarily A aegypti, but also A albopictus), found in tropical and subtropical regions
The infection is endemic in more than 100 countries, particularly the South East Asia region, western Pacific region, and the Americas
The incubation period is 3-14 days (average 7 days)
Clinical features include fever, headache, myalgia/arthralgia, and skin flushing/rash, together with leucopenia, thrombocytopenia, and increased liver function
Severe thrombocytopenia, haemorrhage, and plasma leakage are the key diagnostic features of the more severe forms of infection
Confirmatory tests include detection of viral antigen or nucleic acid and serology
Fluid therapy and the identification of the critical phase are the most important aspects of management
Dengue fever is a globally important arboviral infection transmitted by mosquitoes of the Aedes genus (primarily Aedes aegypti, but also A albopictus), an insect found in tropical and subtropical regions.1 Dengue infection causes a range of severe and non-severe clinical manifestations.2 The incubation period is 3-14 days (average 7 days).
Sources and selection criteria
I searched Medline and PubMed from 1980 to date, limited to publications in English. My search strategy used a combination of key words, including “dengue”, “DHF”, “US”, “Africa”, “Europe”, “Asia”, “WHO”, and “Complications”. I supplemented these sources with selected systematic reviews. Additional information cited includes evidence based national guidelines, published consensus statements, and WHO publications.
Who gets dengue fever?
Around two fifths of the world’s population (those in tropical and subtropical countries), or up to 2.5 …