Letters Phase I studies

Phase I studies: the role of publicly funded academic-healthcare partnerships

BMJ 2015; 351 doi: https://doi.org/10.1136/bmj.h3889 (Published 22 July 2015) Cite this as: BMJ 2015;351:h3889
  1. Nathan J Brendish, clinical research fellow1,
  2. Diane F Gbesemete, clinical research fellow1,
  3. Hans de Graaf, clinical research fellow1,
  4. Christopher J Edwards, director1,
  5. Saul N Faust, director1
  1. 1Southampton National Institute for Health Research Wellcome Trust Clinical Research Facility, University Hospital Southampton NHS Foundation Trust, Southampton General Hospital, Southampton SO16 6YD, UK
  1. nathan.brendish{at}uhs.nhs.uk

Emanuel and colleagues’ meta-analysis found that phase I studies are very safe.1 However, the accompanying editorial mentioned that phase I studies are a “secret realm” and that “most studies are conducted outside academic medical centres at private facilities run by pharmaceutical companies or contract research organisations.” …

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