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Pre-exposure prophylaxis in women fails to prevent HIV infection in African study

BMJ 2015; 350 doi: https://doi.org/10.1136/bmj.h717 (Published 06 February 2015) Cite this as: BMJ 2015;350:h717
  1. Susan Mayor
  1. 1London

Pre-exposure prophylaxis with an oral or vaginal antiretroviral drug failed to reduce HIV-1 infection in a large study of young women in South Africa, Uganda, and Zimbabwe. Blood tests showed poor adherence with the treatment, which is likely to explain the lack of effect.

The study randomised 5029 women aged 18 to 45 (mean age 25.3 years) to daily treatment with 1% tenofovir vaginal gel or placebo or alternatively to oral tenofovir disoproxil fumarate, oral tenofovir …

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