Letters Combined oral contraceptives and venous thromboembolism

Authors’ reply to Zagarella

BMJ 2015; 350 doi: http://dx.doi.org/10.1136/bmj.h3308 (Published 24 June 2015) Cite this as: BMJ 2015;350:h3308
  1. Yana Vinogradova, research statistician,
  2. Carol Coupland, associate professor and reader in medical statistics,
  3. Julia Hippisley-Cox, professor of clinical epidemiology and general practice
  1. 1University of Nottingham, Nottingham, UK
  1. yana.vinogradova{at}nottingham.ac.uk

Zagarella asks whether risks of venous thromboembolism may be different in women with potential symptoms of polycystic ovarian syndrome (PCOS), such as acne and hirsutism, but without a formal diagnosis.1 2 Menstrual disorders and acne were recorded for a large proportion of cases and controls across the databases—23-36% for menstrual disorders and 9-13% for acne—and 1-2% had hirsutism recorded. Although …

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