Letters Metformin in renal disease

Scant evidence on the effectiveness of metformin in type 2 diabetes

BMJ 2015; 350 doi: https://doi.org/10.1136/bmj.h2650 (Published 19 May 2015) Cite this as: BMJ 2015;350:h2650
  1. Thomas L Perry, general internist and university professor1
  1. 1Department of Anaesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada V6T 2B5
  1. tom.perry{at}ti.ubc.ca

Metformin is remarkably safe compared with alternative drugs for type 2 diabetes, although it does cause at least chemical vitamin B12 deficiency.1 2 The “problem” of reduced glomerular filtration can be seen as an advantage for drugs like metformin that are eliminated through the kidney. Reduced …

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