Letters Urinary testing for HPV

Urine testing for HPV: rationale for using first void

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g6252 (Published 15 October 2014) Cite this as: BMJ 2014;349:g6252
  1. Alex Vorsters, researcher1,
  2. Pierre Van Damme, professor1,
  3. Gary Clifford, cancer epidemiologist2
  1. 1Faculty of Medicine and Health Sciences, Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, University of Antwerp, 2610 Antwerpen (Wilrijk), Belgium
  2. 2Infections and Cancer Epidemiology Group, International Agency for Research on Cancer, Lyon, Cedex 08, France
  1. alex.vorsters{at}uantwerpen.be

We agree that urine testing for human papillomavirus (HPV) in cervical cancer screening needs further evaluation, and that the heterogeneity of urine sampling and testing protocols should be resolved.1 2 In particular, attention should be given to the rationale and evidence for using first void urine for HPV testing.

During urination, urine is contaminated by impurities, including …

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