Research News

Treatment for advanced prostate cancer can turn from helpful to harmful, research shows

BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g5712 (Published 18 September 2014) Cite this as: BMJ 2014;349:g5712
  1. Nigel Hawkes
  1. 1London

Treatments for advanced prostate cancer that combine steroids and hormonal therapy can become actively harmful when the steroids encourage genetic mutations that turn the treatment from an inhibitor to an activator of the disease, a team from the Institute of Cancer Research in London and the University of Trento in Italy has found.

This change can be tracked by analysing blood samples for circulating tumour DNA, allowing treatment …

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