Letters Antidepressant use and FDA warnings

Antidepressants increase, rather than decrease, risk of suicidal behaviours in younger patients

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5626 (Published 09 October 2014) Cite this as: BMJ 2014;349:g5626
  1. Thomas J Moore, senior scientist, drug safety and policy1
  1. 1Institute for Safe Medication Practices, Alexandria, VA 22314, USA
  1. tmoore{at}ismp.org

Lu and colleagues’ study contains four substantial flaws, any of which would be fatal to the authors’ premise that Food and Drug Administration warnings about suicide risks of antidepressants led to an increase in suicidal behaviours.1

Firstly, the authors acknowledge that the insurance claims data on which they rely is generally not suitable for detecting …

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