Letters Antidepressant use and FDA warnings

Link between FDA antidepressant warnings and increased suicide attempts in young people is questionable

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5614 (Published 09 October 2014) Cite this as: BMJ 2014;349:g5614
  1. Mark Olfson, professor of psychiatry1,
  2. Michael Schoenbaum, senior adviser for mental health services, epidemiology, and economics2
  1. 1Columbia University Medical Center, New York, NY 10032, USA
  2. 2National Institute of Mental Health , Bethesda, MD, USA
  1. mo49{at}columbia.edu

Lu and colleagues hypothesised that US Food and Drug Administration antidepressant safety warnings reduced antidepressant prescribing and thereby increased suicide attempts in young people.1 They investigated associations in three age groups between antidepressant prescribing before and after the warnings and suicide attempts, as measured by psychotropic poisonings in patients presenting to emergency departments or admitted to hospital. We question their conclusions that …

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