Letters BCG vaccination and TB in children

Authors’ reply to Turner and colleagues

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5441 (Published 10 September 2014) Cite this as: BMJ 2014;349:g5441
  1. I Abubakar, professor of infectious disease epidemiology1,
  2. S Sridhar, research associate2,
  3. M Eisenhut, consultant paediatrician3,
  4. A Roy, senior scientist4,
  5. R J Harris, statistician4,
  6. L C Rodrigues, professor of epidemiology5,
  7. P Mangtani, senior lecturer5,
  8. I Adetifa, paediatrician and medical epidemiologist6,
  9. A Lalvani, professor of infectious disease2
  1. 1Centre for Infectious Disease Epidemiology and MRC Clinical Trials Unit, University College London, London, UK
  2. 2Tuberculosis Research Centre, Respiratory Infections Section, National Heart and Lung Institute, Imperial College London, London, UK
  3. 3Luton and Dunstable University Hospital, NHS Foundation Trust, Luton, UK
  4. 4Centre for Infectious Disease Surveillance and Control, Public Health England, London, UK
  5. 5London School of Hygiene and Tropical Medicine, London, UK
  6. 6Medical Research Council, Fajara, Gambia
  1. i.abubakar{at}ucl.ac.uk

Turner and colleagues do not accept our conclusion that BCG prevents Mycobacterium tuberculosis infection without a valid mechanism and propose an alternative hypothesis for an apparent effect.1 2 We presented the consistent epidemiological finding of a protective effect of BCG against tuberculosis infection rather than speculating on a mechanism of action for this …

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