Letters Macrolides and infantile hypertrophic pyloric stenosis

The difficulty in evaluating all findings in study on use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5201 (Published 19 August 2014) Cite this as: BMJ 2014;349:g5201
  1. Frank de Vries, pharmacoepidemiologist1
  1. 1Utrecht Institute for Pharmaceutical Sciences, Universiteitsweg 99, Utrecht, the Netherlands
  1. f.devries{at}uu.nl

Lund and colleagues report a 30-fold risk of infantile hypertrophic pyloric stenosis with the use of macrolide antibiotics during the first 0-13 days of a child’s life.1 This is either a very strong association or too good to be true.

The authors used the Danish national databases, which linked the dispensing of drugs from community …

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