Research News

Gene mutation may increase risk of breast cancer by up to nine times

BMJ 2014; 349 doi: https://doi.org/10.1136/bmj.g5090 (Published 11 August 2014) Cite this as: BMJ 2014;349:g5090
  1. Michael McCarthy
  1. 1Seattle

A mutation in a gene that plays a key role in the proper functioning of the so called “breast cancer genes” BRCA1 and BRCA2 increases the risk of developing breast cancer by nine times in younger women and by five times in older women, a new study has found.1

In the study, researchers analysed the risk of breast cancer in women and men from families who had germline loss-of-function mutations in a gene called PALB2 (partner and localiser of BRCA2). Loss-of-function mutations in both alleles of PALB2—which is also known as FANCN—cause Fanconi’s anaemia, …

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