Letters Vitamin D and mortality

Are trials of vitamin D with mortality as an endpoint really needed?

BMJ 2014; 349 doi: http://dx.doi.org/10.1136/bmj.g4452 (Published 09 July 2014) Cite this as: BMJ 2014;349:g4452
  1. Mark J Bolland, associate professor of medicine1,
  2. Andrew Grey, associate professor of medicine1
  1. 1University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
  1. m.bolland{at}auckland.ac.nz

In a patient level meta-analysis of observational studies, Schottker and colleagues report that low 25-hydroxyvitamin D is associated with a 50% increase in mortality, mostly in people with 25-hydroxyvitamin D levels below the median.1 These results are similar to earlier study level meta-analyses of observational studies.2 Because results from observational studies may not adequately account for confounding and cannot be used to …

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