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Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

BMJ 2014; 348 doi: https://doi.org/10.1136/bmj.g3596 (Published 18 June 2014) Cite this as: BMJ 2014;348:g3596

Re: Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study

In the spirit of Lu et al’s (1) warning not to sound alarms about antidepressant use prematurely, we used readily available national data to investigate whether youth suicide attempts in the U.S. increased after 2003 and 2004—the years in which the FDA issued warnings about antidepressant safety. Attempts did not increase. Lu et al’s opposite finding probably has more to do with the unusual proxy they used (one they said was validated by a paper that two of us—MM and CB—co-authored) than with an actual change in suicidal behavior among youth. We briefly summarize here five readily available, online data sources that provide more direct and valid measures of youth suicidal behavior, and we discuss problems with the proxy that Lu’s study used.

The CDC’s Youth Risk Behavior Survey (YRBS) is a pencil-and-paper questionnaire filled out by high school students (3). There was no increase in self-reported suicide attempts from 2003 to 2005 according to the YRBS (see Figure 1); in fact, there was a decline in suicidal thoughts, plans, and medically-treated attempts from the late ‘90s through 2009 (with some increases in more recent years). Two databases that estimate national hospital visit rates based on a sample of hospitals also saw no increase in youth self-harm following 2004. The first is the Health Care Utilization Project’s (HCUP) online database (4), which shows no increase in inpatient discharges for intentional self-harm diagnoses (E950-E959) among those ages 17 and under. The CDC’s WISQARS-Nonfatal database (5) also shows no increase in emergency department care for self-harm in this age group (although numbers jump around from year to year). Both HCUP and WISQARS-Nonfatal are estimates based on a national sample of hospitals and thus subject to sampling error. California’s EPIC website, on the other hand, presents a census of inpatient discharges for the entire state (6). There, too, no increases in self-harm hospitalization rates among children, adolescents, and young adults were observed following the FDA warnings. Finally, and most consequently, according to official mortality data available on the CDC WISQARS-Fatal website (5), the suicide rate among youth was largely flat 2000-2010, with an increase in 2011.

Lu’s study findings are roundly unsupported by national data. While the national and California data sources have limitations, each is a more direct indicator of intentional self-harm than the data Lu et al used. Lu et al used poisonings by psychotropics (ICD-9 code 969) as a proxy for suicide attempts in claims data from 11 health plans, in spite of the fact that the code covers both intentional and unintentional poisonings. Our paper, which is the sole reference to their claim that code 969 is a “validated” proxy for suicide attempts, in fact shows that in the U.S. National Inpatient Sample the code has a sensitivity of just 40% (i.e., it misses 60% of discharges coded to intentional self-harm) and a positive predictive value of 67% (i.e., a third of the discharges it captures are not intentional self-harm).

On balance, the evidence shows no increase in suicidal behavior among young people following the drop in antidepressant prescribing. It is important that we get this right because the safety of young people is at stake. Lu et al’s paper sounding the alarm that attempts increased was extensively covered in the media. Their advice that the media should be more circumspect when covering dire warnings about antidepressant prescribing applies as well to their own paper.

References:

1 Lu CY, Zhang F, Lakoma MD, et al. Changes in antidepressant use by young people and suicidal behavior after FDA warnings and media coverage: quasi-experimental study. BMJ. 2014;348:g3596.
2 Patrick AR, Miller M, Barber C, et al. Identification of hospitalizations for intentional self-harm when E-codes are incompletely recorded. Pharmacoepidemiol Drug Saf. 2010;19(12):1263-75.
3 Youth Risk Behavior Surveillance System. Trends in the Prevalence of Suicide-Related Behaviors, National YRBS: 1997-2011. Available online at: http://www.cdc.gov/healthyyouth/yrbs/pdf/us_suicide_trend_yrbs.pdf Accessed 6/19/14.
4 HCUPnet. Healthcare Cost and Utilization Project (HCUP). National Inpatient Sample. Agency for Healthcare Research and Quality, Rockville, MD. Available online at: http://hcupnet.ahrq.gov/ Accessed 6/19/14.
5 Centers for Disease Control and Prevention (CDC). Web-based Injury Statistics Query and Reporting System (WISQARS) [Online]. (2003). National Center for Injury Prevention and Control, CDC (producer). Available online at: www.cdc.gov/ncipc/wisqars. Accessed 6/19/14.
6 California Office of Statewide Health Planning and Development, Inpatient Discharge Data. California Department of Public Health, Safe and Active Communities Branch. Available online at: http://epicenter.cdph.ca.gov . Accessed 6/20/14.

Competing interests: No competing interests

14 July 2014
Catherine W Barber
Researcher
Matthew Miller, Deborah Azrael (Harvard School of Public Health)
Harvard School of Public Health
677 Huntington Avenue, 3rd floor, Boston MA 02115