Letters Vitamin D and multiple outcomes

Causal link between vitamin D deficiency and ill health still possible

BMJ 2014; 348 doi: https://doi.org/10.1136/bmj.g2923 (Published 29 April 2014) Cite this as: BMJ 2014;348:g2923
  1. Barbara J Boucher, honorary professor1
  1. 1Blizard Institute, Bart’s and the London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, UK
  1. bboucher{at}doctors.org.uk

The two BMJ articles suggest that vitamin D supplementation has limited benefits.1 2 However, their findings could be compromised by non-adjustment for several factors—inclusion of the same study data in several meta-analyses reviewed; benefits only at higher intakes (fracture reduction in older women) or with baseline deficiency (muscle strength); “thresholds” for detectable benefits (insulin resistance when final 25 hydroxyvitamin D ≥80 nmol/L); and non-exclusion …

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