Letters Fluid replacement

Time to assess alternatives to hydroxyethyl starch to use instead of 0.9% saline in fluid replacement

BMJ 2013; 347 doi: https://doi.org/10.1136/bmj.f4651 (Published 30 July 2013) Cite this as: BMJ 2013;347:f4651
  1. Mairi Cruickshanks, foundation doctor1,
  2. Gordon B Drummond, honorary senior lecturer2,
  3. Simon Paterson-Brown, consultant upper GI surgeon2,
  4. Arfon G M T Powell, clinical research fellow3
  1. 1Glasgow Royal Infirmary, Glasgow G4 0SF, UK
  2. 2Royal Infirmary, Edinburgh EH16 4SA, UK
  3. 3Unit of Experimental Therapeutics, College of Medical, Veterinary and Life of Sciences, 2nd Floor McGregor Building, Western General Hospital, Glasgow G12 8QQ, UK
  1. mairicru{at}hotmail.com

Intravenous fluids containing hydroxyethyl starch have been withdrawn from use in acutely unwell patients in the UK following a recommendation by the Medicines and Healthcare Products Regulatory Agency (MHRA).1 This recommendation was based on findings by Haase and colleagues that hydroxyethyl starch compared with crystalloids or albumin was associated with an increased need for renal replacement therapy and blood transfusion …

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