The nephrotoxic “triple whammy” of combining diuretics, ACE inhibitors, and diureticsBMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f678 (Published 19 February 2013) Cite this as: BMJ 2013;346:f678
- Macaulay A Onuigbo, nephrologist and hypertension specialist1
- 1Mayo Clinic, Rochester, MN, and Mayo Clinic Health System, Eau Claire, WI, USA
Lapi and colleagues identified 2215 cases of acute kidney injury (AKI) during follow-up—an overall incidence of 7 in 10 000 (95% CI 7/10 000 to 8/10 000) person years.1 A recent US study reported a rapidly increasing incidence of serious AKI requiring dialysis—from 222 cases per million person years in 2000 to 533 cases per …
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