Sentinel node biopsy for melanoma

Where is the evidence base for benefits of sentinel node biopsy in melanoma?

BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f675 (Published 6 February 2013)
Cite this as: BMJ 2013;346:f675

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  1. J Meirion Thomas, professor of surgical oncology1
  1. 1Royal Marsden Hospital, London SW3 6JJ, UK
  1. meirion{at}roseway.demon.co.uk

Sentinel node biopsy (SNB) has been promoted by claims of a survival advantage after early lymphadenectomy in patients with a positive result. The pivotal paper states that SNB “identifies patients with nodal metastases whose survival can be prolonged by immediate lymphadenectomy.”1 An earlier paper by Morton and colleagues states, “Our data suggest a significant therapeutic benefit for immediate …

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