Tamiflu: 14 flu seasons and still questions

BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f547 (Published 25 January 2013)
Cite this as: BMJ 2013;346:f547

Get access to this article and all of bmj.com for the next 14 days

Sign up for a 14 day free trial today

Access to the full text of this article requires a subscription or payment. Please log in or subscribe below.

  1. Harlan M Krumholz, Harold H Hines Jr professor of medicine1,
  2. Cynthia A Jackevicius, associate professor, pharmacy practice2,
  3. Joseph S Ross, assistant professor1
  1. 1Yale University School of Medicine, New Haven, CT 06510, USA
  2. 2College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA
  1. harlan.krumholz{at}yale.edu

At best, and bearing in mind missing data, the drug shortens flu symptoms by a day

In the midst of a worse than average influenza season, clinicians are increasingly prescribing antiviral agents, especially oseltamivir (Tamiflu). Oseltamivir, an oral neuraminidase inhibitor, was first approved for use by the US Food and Drug Administration in 1999. It is indicated “for the treatment of acute, uncomplicated illness due to influenza infection in patients 2 weeks of age and older who have been symptomatic for no more than two days,” and, “for the prophylaxis of influenza in patients 1 year and older,” with similar indications worldwide. Despite these broad indications, some government agencies promote even wider use. For instance, the website of the US Department of Health and Human Services states that oseltamivir may prevent serious complications of flu, and the US Centers for Disease Control and Prevention’s website states that early antiviral treatment may reduce the risk of complications of flu and death.1 2 Business analysts expect rising sales of oseltamivir to reach $750m (£474m; €562m) this year alone.3

Despite such enthusiasm, some basic questions remain unanswered, including the most crucial: what do we really know about oseltamivir’s effectiveness and who benefits from treatment? With the huge number of people affected and such remarkable sales, the evidence to support the …

Get access to this article and all of bmj.com for the next 14 days

Sign up for a 14 day free trial today

Access to the full text of this article requires a subscription or payment. Please log in or subscribe below.

Article access

Article access for 1 day

Purchase this article for £20 $30 €32*

The PDF version can be downloaded as your personal record

* Prices do not include VAT

THIS WEEK'S POLL