Co prescription of statins and antibiotics linked to extra deaths

BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f3963 (Published 18 June 2013)
Cite this as: BMJ 2013;346:f3963

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Evidence is growing of an important drug interaction between widely used statins and antibiotics. Clarithromycin and erythromycin inhibit the cytochrome P450 isoenzyme that metabolises atorvastatin, simvastatin, and lovastatin. Co-prescription of any combination of these statins and antibiotics increases blood concentrations of the statin, …

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