Letters
Hormonal contraception and thrombosis
Authors’ reply to Costescu and Waddington
BMJ 2013; 346 doi: https://doi.org/10.1136/bmj.f2369 (Published 16 April 2013) Cite this as: BMJ 2013;346:f2369
- Frits R Rosendaal, professor in clinical epidemiology1,
- Frans M Helmerhorst, professor in clinical epidemiology of fertility1
- 1Leiden University Medical Center, 2300 RC Leiden, Netherlands
- F.R.Rosendaal{at}lumc.nl
Costescu and Waddington think that there is no reason for a European Medicines Agency review or any concern because oral contraceptives containing third generation progestogens, drospirenone, and cyprotereone acetate are all equally safe.1 2
Their main point is that all retrospective studies are fraught with bias. Undoubtedly, any study can be biased—we dealt with this point more than …
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