- Philip Sedgwick, reader in medical statistics and medical education
- 1Centre for Medical and Healthcare Education, St George’s, University of London, Tooting, London, UK
Researchers evaluated the effect of initial trophic feeding compared with full enteral feeding on physical function in patients with acute lung injury. A cluster randomised controlled trial study design was used. In total, 525 patients with acute lung injury admitted to hospital were recruited. Participants were randomised to low energy permissive underfeeding (“trophic feeding”) or full energy enteral feeding (“full feeding”) for up to six days; thereafter, all patients still receiving mechanical ventilation received full feeding.1
The primary outcome was blind assessment of the physical function domain of the SF-36 instrument, adjusted for age and sex, 12 months after …
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