Letters
Dual blockade of the renin-angiotensin system
Authors’ reply to Laragh and Sealey
BMJ 2013; 346 doi: https://doi.org/10.1136/bmj.f1689 (Published 19 March 2013) Cite this as: BMJ 2013;346:f1689
- Franz H Messerli, professor of clinical medicine1,
- Harikrishna Makani, fellow in cardiovascular medicine1,
- Sripal Bangalore, director of cardiovascular outcomes group, assistant professor of medicine2
- 1St Luke’s Roosevelt Hospital, Columbia University College of Physicians and Surgeons, New York, NY 10019, USA
- 2Leon H Charney Division of Cardiology, New York University School of Medicine, New York, NY, USA
- messerli.f{at}gmail.com
We agree with Laragh and Sealey that sodium and volume depletion increase the risk of adverse events of renin-angiotensin system blockade. Indeed, protection against hypotension due to volume depletion is one of the main physiological functions of the renin-angiotensin system in people with normal and high blood pressure.1 2
As the …
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