Paracetamol hepatotoxicity

Is paracetamol hepatotoxic at normal doses?

BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f1519 (Published 12 March 2013)
Cite this as: BMJ 2013;346:f1519

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  1. Nicholas D Moore, clinical pharmacologist1,
  2. Ezgi Gulmez, associate professor in pharmacoepidemiology1,
  3. Patrick Blin, senior scientific officer1
  1. 1Department of Pharmacology, University of Bordeaux, Inserm U657-CIC-P005, 33076 Bordeaux, France
  1. nicholas.moore{at}pharmaco.u-bordeaux2.fr

We note that the number of registrations for hepatic transplantation for paracetamol overdose found in SALT (Study of Acute Liver Transplantation) in the UK1—63 cases in 2005-07 (5.25 cases per quarter)—was the same as that reported by Hawton and colleagues.2

However, in the UK and …

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