Exclusion of suspect data raises question mark over safety of common plasma substitute

BMJ 2013; 346 doi: http://dx.doi.org/10.1136/bmj.f1132 (Published 19 February 2013)
Cite this as: BMJ 2013;346:f1132

Get access to this article and all of bmj.com for the next 14 days

Sign up for a 14 day free trial today

Access to the full text of this article requires a subscription or payment. Please log in or subscribe below.

  1. Susan Mayor
  1. 1London

Hydroxyethyl starch, a commonly used plasma substitute, is associated with increased risk of death and acute kidney injury in critically ill patients needing an increase in blood fluid volume, according to a new meta-analysis1 that excluded trials from an investigator some of whose research has been retracted because of scientific misconduct.

“This study highlights the serious implications of scientific misconduct on patient safety,” warned Massimo Antonelli, professor of intensive care medicine at the Università Cattolica del Sacro Cuore, Rome, Italy, in an accompanying editorial.2 He added that it illustrated the importance of updating guidelines regularly as the evidence base changes.

Synthetic colloids such as hydroxyethyl starch were approved in the 1960s without …

Get access to this article and all of bmj.com for the next 14 days

Sign up for a 14 day free trial today

Access to the full text of this article requires a subscription or payment. Please log in or subscribe below.

Article access

Article access for 1 day

Purchase this article for £20 $30 €32*

The PDF version can be downloaded as your personal record

* Prices do not include VAT

THIS WEEK'S POLL