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Evidence for and against aldosterone antagonists in heart failure

BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e8024 (Published 27 November 2012) Cite this as: BMJ 2012;345:e8024

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Randomised trials and observational studies often disagree. Usually, observational studies suggest that an intervention works but rigorous trials fail to confirm this. The opposite occurred in studies evaluating spironolactone and other aldosterone antagonists for adults with heart failure. Trials show that these drugs can save lives …

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