Intended for healthcare professionals

Rapid response to:

Practice A Patient’s Journey

Fatigue in primary biliary cirrhosis

BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e7004 (Published 22 October 2012) Cite this as: BMJ 2012;345:e7004

Rapid Response:

Re: Fatigue in primary biliary cirrhosis

With due sympathy to the patient, primary or secondary cirrhosis is not a neoplasm but a benign condition. Due to bile obstruction in any intra-hepatic bile channel, the flattened tubular hepatic acini sandwich between sinusoids, get distended causing pressure atrophy of peri-bile-canalicular hepatocytes, rupture, fibrosis contributed by perisinusoidal linings, and reparative hyperplasia of the surviving hepatocytes. Hepatic fiberoptic cholengiography and sinusoid angiography should be possible in this age of hepatic transplantation. But no reports are visible on any cholengio vascular obstruction removal or plasty in liver for cure of benign obstructive life threatening lesions spreading on the abdomen wall that vessels are blocked.

Competing interests: No competing interests

30 October 2012
Mohammed Naim
Professor, Pathology
JNMC AMU Aligarh India
JNMC AMU Aligarh 202002 India