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Is chloride in intravenous fluids nephrotoxic?

BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e6940 (Published 17 October 2012)
Cite this as: BMJ 2012;345:e6940

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JAMA2012;308:1566-72OpenUrlCrossRef

When one intensive care unit in Australia reduced the chloride content of permitted intravenous fluids, patients’ renal function improved significantly. The incidence of acute kidney injury and use of renal replacement therapy fell. In addition, serum creatinine concentrations rose less sharply than they had …

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