Letters Updated version of QRISK2

Being sanguine about study design and multiple imputation

BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e5884 (Published 10 September 2012) Cite this as: BMJ 2012;345:e5884
  1. Sheila M Bird, medical statistician1
  1. 1MRC Biostatistics Unit, Cambridge CB2 0SR, UK
  1. sheila.bird{at}mrc-bsu.cam.ac.uk

Using The Health Improvement Network (THIN) database, Collins and Altman validate QRISK2-2011 versus the National Institute for Health and Clinical Excellence’s Framingham Equation (NFE) for predicting 10 year risk of cardiovascular disease.1

The QRISK2-2011 web calculator replaces missing data via multiple imputation predictor algorithms. Would I want my risk assessed on imputed data or prefer my GP to determine which data to obtain? …

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