Letters PPIs with clopidogrel

Author’s reply to Witham and colleagues

BMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e5852 (Published 04 September 2012) Cite this as: BMJ 2012;345:e5852
  1. Laura Targownik, associate professor of medicine1
  1. 1Section of Gastroenterology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada R3N 0V6
  1. targowni{at}cc.umanitoba.ca

Witham and colleagues express concern about my recommendation to consider co-prescribing proton pump inhibitors (PPIs) for patients using concomitant aspirin and clopidogrel for prevention of cardiovascular complications because of the associated medical complications.1 2 They go on to state that the increased risk of serious gastrointestinal complications associated with dual antiplatelet treatment has been shown only …

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