Laboratory controlled trials are different from clinical trialsBMJ 2012; 345 doi: https://doi.org/10.1136/bmj.e5425 (Published 14 August 2012) Cite this as: BMJ 2012;345:e5425
- James A Betts, senior lecturer1
- 1Department for Health, University of Bath, Bath BA2 7AY, UK
Heneghan and colleagues deemed many highly regarded studies to be of low quality and at high risk of bias.1 It is therefore essential to consider whether they used appropriate criteria to evaluate studies. Their method to determine risk of bias is more commonly used to evaluate clinical trials so it places heavy emphasis on controlling for deciphering treatment or group allocation, blinding, and thus avoidance of demand characteristics or placebo …
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