Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study

BMJ 2012; 345 doi: http://dx.doi.org/10.1136/bmj.e4389 (Published 24 July 2012)
Cite this as: BMJ 2012;345:e4389

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Leslie and colleagues note their findings of over diagnosis of malaria in two Afghan provinces [1] is consistent with previous reports from Tanzania [2]. Unfortunately, in my experience, little has changed in Tanzania where I recently undertook voluntary work in a health centre close to a university hospital. In almost all cases when microscopy was requested for suspected cases of malaria, the patient was treated with antimalarial drugs independent of the laboratory result. This not to say that laboratory results were particularly accurate, as slides were merely glanced at with seemingly random results given; on several occasions I handed the same technician the same slide twice and it went from a very high positive result to a negative or vice versa.

There were several reasons that I observed for over diagnosis of malaria in the clinic. First, the doctors were paid more for prescribing greater numbers of antimalarial drugs: in fact one doctor who did not diagnose malaria in what was considered by the owner to be enough patients, was called up to the owner's office on several occasions, and had both his pay and work hours cut because he was not bringing in a high enough profit. Secondly, the laboratory staff were poorly trained. Three staff worked in the laboratory of whom only one had undergone training. Moreover laboratory staff received pay and extra working hours based on the number of patients they diagnosed with malaria: the only trained member of staff had the lowest number of working hours due to the low number of positives coming out of the laboratory when she was working. Lack of accurate laboratory results led, of course, to lack of trust in these results, and thus if the doctor had already decided on a clinical diagnosis of malaria, he would almost inevitably prescribe antimalarials, and laboratory tests were merely a formality used in order to bring in further profit to the health centre.

Leslie and colleagues propose several reasons why health professionals may prescribe inappropriately, but in countries such as Afghanistan and Tanzania where health workers' pay is far lower than in the UK, financial incentives to over treat should be considered.

References
1. Leslie T, Mikhail A, Mayan I, Anwar M, Bakhtash S, Nader M, Chandler C, Whitty C JM, Rowland M. Overdiagnosis and mistreatment of malaria among febrile patients at primary healthcare level in Afghanistan: observational study. BMJ 2012;345:e4389
2. Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ 2004;329:1212.

Competing interests: None declared

Robert J Starr, Medical Student

University of Aberdeen, School of Medicine and Dentistry, Aberdeen University, Foresterhill, Aberdeen, UK. AB25 2ZD.

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Whilst working in a rural hospital in Ghana last year I also observed many patients being treated for malaria despite negative microscopy. The hospital dedicated its limited resources to providing an efficient microscopy service and so it was striking that clinicians held the results in such low esteem.

The clinicians maintained that they worked in an endemic area and this fact was used to justify mistreatment of microscopy-negative patients. The laboratory staff were far more familiar with the local incidence of malaria and the seasonal variance in their results. Sadly, my efforts to encourage better communication between clinicians and the laboratory met with little success. I wonder if the authors of this study had any more luck encouraging local clinicians to trust microscopy results?

Competing interests: None declared

Luke Yates, Foundation year doctor

NHS Highland, 21H Cairn Court, Raigmore Hospital staff accommodation, Inverness, IV2 3UJ

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